A new planar multielectrode array for extracellular recording: application to hippocampal acute slice

被引：241

作者：

Oka, H ^{[1
]}

Shimono, K ^{[1
]}

Ogawa, R ^{[1
]}

Sugihara, H ^{[1
]}

Taketani, M ^{[1
]}

机构：

[1] Matsushita Elect Ind Co Ltd, Hlth & Med Care Planning Off, Corp Res Div, Sora Ku, Kyoto 6190237, Japan

来源：

JOURNAL OF NEUROSCIENCE METHODS | 1999年 / 93卷 / 01期

关键词：

multi-channel; acute slice; fEPSP; LTP;

D O I：

10.1016/S0165-0270(99)00113-2

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The present paper describes a new planar multielectrode array (the MED probe) and its electronics (the MED system) which perform electrophysiological studies on acute hippocampal slices. The MED probe has 64 planar microelectrodes, is covered with a non-toxic, uniform insulation layer, and is further coated with polyethylenimine and serum. The MED probe is shown to be appropriate for both stimulation and recording. In particular, multi-channel recordings of field EPSPs obtained by stimulating with a pair of planar microelectrodes were established for rat hippocampal acute slices. The recordings were stable for 6 h. Finally a spatial distribution of long-term potentiation was studied using the MED system. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：61 / 67

页数：7

共 10 条

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[Anonymous], BRAIN SLICES

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