MUC1 (CD227): a multi-tasked molecule

被引：117

作者：

Apostolopoulos, Vasso ^{[1
]}

Stojanovska, Lily ^{[1
]}

Gargosky, Sharron E. ^{[2
]}

机构：

[1] Victoria Univ, Coll Hlth & Biomed, Ctr Chron Dis, Melbourne, Vic 8001, Australia

[2] Prima BioMed Ltd, Sydney, NSW, Australia

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2015年 / 72卷 / 23期

关键词：

MUC1; CD227; PEM; EMA; isoforms; expression; structure; MUC1 and disease; MUC1 and pathogens; MUC1 and cancer; MEMBRANE-ASSOCIATED MUCINS; TUMOR-ANTIGEN MUC1; HUMAN T-CELLS; CARCINOMA-ASSOCIATED ANTIGEN; MULTIPLE-MYELOMA CELLS; LUNG EPITHELIAL-CELLS; FAT GLOBULE-MEMBRANE; BREAST-CANCER; MONOCLONAL-ANTIBODIES; GENE-EXPRESSION;

D O I：

10.1007/s00018-015-2014-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Mucin 1 (MUC1 [CD227]) is a high-molecular weight (> 400 kDa), type I membrane-tethered glycoprotein that is expressed on epithelial cells and extends far above the glycocalyx. MUC1 is overexpressed and aberrantly glycosylated in adenocarcinomas and in hematological malignancies. As a result, MUC1 has been a target for tumor immunotherapeutic studies in mice and in humans. MUC1 has been shown to have anti-adhesive and immunosuppressive properties, protects against infections, and is involved in the oncogenic process as well as in cell signaling. In addition, MUC1 plays a key role in the reproductive tract, in the immune system (affecting dendritic cells, monocytes, T cells, and B cells), and in chronic inflammatory diseases. Evidence for all of these roles for MUC1 is discussed herein and demonstrates that MUC1 is truly a multitasked molecule.

引用

页码：4475 / 4500

页数：26

共 244 条

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MUC1 mucin-mediated regulation of human T cells [J].