A novel hepatitis B virus mutation with resistance to adefovir but not to tenofovir in an HIV-hepatitis B virus-co-infected patient

被引：32

作者：

Lacombe, Karine ^{[1
]}

Ollivet, Aurelie

Gozlan, Joel

Durantel, Sandra

Tran, Nathalie

Girard, Pierre-Marie

Zoulim, Fabien

机构：

[1] INSERM, U707, F-75012 Paris, France

[2] Univ Paris 06, F-75012 Paris, France

[3] Hop St Antoine, AP HP, Serv Malad Infect & Trop, F-75012 Paris, France

[4] INSEAD, U271, Lab Virus Hepat & Pathol Assoc, F-69000 Lyon, France

[5] Univ Paris 06, UMR 7079, Ctr Rech Cordeliers, F-75005 Paris, France

[6] Hop Hotel Dieu, Serv Hepatol, Hospices Civils Lyon, F-69288 Lyon, France

[7] Lab Biomerieux, Marcy Letoile, France

来源：

AIDS | 2006年 / 20卷 / 17期

关键词：

D O I：

10.1097/01.aids.0000252061.35422.84

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A molecular virology analysis performed in an HIV-hepatitis B virus (HBV) co-infected patient showed the emergence of an unusual HBV polymerase gene mutation (rt A181T) under adefovir therapy, conferring resistance to adefovir but not to tenofovir, as proved by in-vitro phenotypic analysis. This observation suggests that careful monitoring of co-infected patients is required to diagnose HBV resistance to nucleos(t)ide analogues, and that tenofovir may be active at least against some of the adefovir-resistant strains.

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收藏

页码：2229 / 2231

页数：3

相关论文

共 10 条

[1] Resistance to adefovir dipivoxil therapy associated with the selection of a novel mutation in the HBV polymerase [J].

Angus, P ;

Vaughan, R ;

Xiong, S ;

Yang, HL ;

Delaney, W ;

Gibbs, C ;

Brosgart, C ;

Colledge, D ;

Edwards, R ;

Ayres, A ;

Bartholomeusz, A ;

Locarnini, S .

GASTROENTEROLOGY, 2003, 125 (02) :292-297

[2] Safety and efficacy of adefovir dipivoxil in patients infected with lamivudine-resistant hepatitis B and HIV-1 [J].

Benhamou, Y ;

Thibault, V ;

Vig, P ;

Calvez, V ;

Marcelin, AG ;

Fievet, MN ;

Currie, G ;

Chang, CG ;

Biao, L ;

Xiong, S ;

Brosgart, C ;

Poynard, T .

JOURNAL OF HEPATOLOGY, 2006, 44 (01) :62-67

[3] Tenofovir disoproxil fumarate in patients with HIV and lamivudine-resistant hepatitis B virus. [J].

Benhamou, Y ;

Tubiana, R ;

Thibault, V .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (02) :177-178

[4] Long-term incidence of hepatitis B virus resistance to lamivudine in human immunodeficiency virus-infected patients [J].

Benhamou, Y ;

Bochet, M ;

Thibault, V ;

Di Martino, V ;

Caumes, E ;

Bricaire, F ;

Opolon, P ;

Katlama, C ;

Poynard, T .

HEPATOLOGY, 1999, 30 (05) :1302-1306

[5] A new strategy for studying in vitro the drug susceptibility of clinical isolates of human hepatitis B virus [J].

Durantel, D ;

Carrouée-Durantel, S ;

Werle-Lapostolle, B ;

Brunelle, MN ;

Pichoud, C ;

Trépo, C ;

Zoulim, F .

HEPATOLOGY, 2004, 40 (04) :855-864

[6] Major role of hepatitis B genotypes in liver fibrosis during coinfection with HIV [J].

Lacombe, K ;

Massari, V ;

Girard, PM ;

Serfaty, L ;

Gozlan, J ;

Pialoux, G ;

Mialhes, P ;

Molina, JM ;

Lascoux-Combe, C ;

Wendum, D ;

Carrat, F ;

Zoulim, F .

AIDS, 2006, 20 (03) :419-427

[7] Long-term hepatitis B virus dynamics in HIV-hepatitis B virus-co-infected patients treated with tenofovir disoproxil fumarate [J].

Lacombe, K ;

Gozlan, J ;

Boelle, PY ;

Serfaty, L ;

Zoulim, F ;

Valleron, AJ ;

Girard, PM .

AIDS, 2005, 19 (09) :907-915

[8] Brief report: Variant of hepatitis B virus with primary resistance to adefovir [J].

Schildgen, O ;

Sirma, H ;

Funk, A ;

Olotu, C ;

Wend, UC ;

Hartmann, H ;

Helm, M ;

Rockstroh, JK ;

Willems, WR ;

Will, H ;

Gerlich, WH .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (17) :1807-1812

[9] Selection of a hepatitis B virus strain resistant to adefovir in a liver transplantation patient [J].

Villeneuve, JP ;

Durantel, D ;

Durantel, S ;

Westland, C ;

Xiong, S ;

Brosgart, CL ;

Gibbs, CS ;

Parvaz, P ;

Werle, B ;

Trépo, C ;

Zoulim, F .

JOURNAL OF HEPATOLOGY, 2003, 39 (06) :1085-1089

[10]

Zoulim F, 2004, ANTIVIR RES, V64, P1, DOI 10.1016/S0166-3542(04)00162-7