Chemistry and biology of the tetrahydroisoquinoline antitumor antibiotics

被引：1075

作者：

Scott, JD ^{[1
]}

Williams, RM ^{[1
]}

机构：

[1] Colorado State Univ, Dept Chem, Ft Collins, CO 80523 USA

来源：

CHEMICAL REVIEWS | 2002年 / 102卷 / 05期

关键词：

D O I：

10.1021/cr010212u

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The tetrahydroisoquinoline family of antitumor antibiotics constitutes a small yet growing and increasingly important family of chemotherapeutic agents. A diverse range of biochemical and biological activities are exhibited by this family of compounds. This review details a myriad of subtle structural and stereoelectronic issues. The information given provides for an interesting mechanistic playing field for the future design and synthesis of potentially biologically significant agents.

引用

页码：1669 / 1730

页数：62

共 218 条

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