Identification of G protein-coupled receptor genes from the human genome sequence

被引：281

作者：

Takeda, S

Kadowaki, S

Haga, T

Takaesu, H

Mitaku, S

机构：

[1] Univ Tokyo, Fac Med, Dept Neurochem, Bunkyo Ku, Tokyo 1130033, Japan

[2] Gakushuin Univ, Fac Sci, Inst Biomol Sci, Toshima Ku, Tokyo 1718588, Japan

[3] Tokyo Univ Agr & Technol, Fac Engn, Dept Biotechnol, Tokyo 1848588, Japan

[4] Japan Sci & Technol Corp, Tokyo, Japan

来源：

FEBS LETTERS | 2002年 / 520卷 / 1-3期

基金：

日本学术振兴会;

关键词：

G protein-coupled receptor; genome; G protein; proteomics; ligand screening; orphan receptor;

D O I：

10.1016/S0014-5793(02)02775-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have identified novel G protein-coupled receptors (GPCRs) with no introns in the coding region from the human genome sequence: 322 olfactory receptors; 22 taste receptors; 128 registered GPCRs for endogenous ligands; 50 novel GPCR candidates homologous to registered GPCRs for endogenous ligands; and 59 novel GPCR candidates not homologous to registered GPCRs. The total number of GPCRs with and without introns in the human genome was estimated to be approximately 950, of which 500 are odorant or taste receptors and 450 are receptors for endogenous ligands. (C) 2002 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.

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页码：97 / 101

页数：5

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