Niobium-catalyzed reduction of monofluoroarenes with LiAlH4

被引：28

作者：

Fuchibe, K ^{[1
]}

Akiyama, T ^{[1
]}

机构：

[1] Gakushuin Univ, Fac Sci, Dept Chem, Toshima Ku, Tokyo 1718588, Japan

来源：

SYNLETT | 2004年 / 07期

关键词：

fluorine; reductions; nucleophilic aromatic substitutions; niobium; hydrodefluorination catalyst;

D O I：

10.1055/s-2004-822919

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

It was found that monofluoroarenes were reduced to the corresponding hydrodefluorinated arenes by the treatment of 5 mol% of NbCl5 and LiAlH4. Based on the substituent effect observed, an aromatic nucleophilic substitution mechanism is proposed.

引用

页码：1282 / 1284

页数：3

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