Addiction and arousal: Alternative roles of hypothalamic peptides

被引：62

作者：

de Lecea, Luis

Jones, Barbara E.

Boutrel, Benjamin

Borgland, Stephanie L.

Nishino, Seiji

Bubser, Michael

DiLeone, Ralph

机构：

[1] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Palo Alto, CA 94304 USA

[2] McGill Univ, Dept Neurol & Neurosurg, Montreal, PQ H3A 2T5, Canada

[3] CHU Vaudois, Hop Cery, CH-1011 Lausanne, Switzerland

[4] Univ Calif San Francisco, Dept Neurobiol, Ernest Gallo Clin & Res Ctr, San Francisco, CA 94608 USA

[5] Vanderbilt Univ, Med Ctr, Dept Psychiat, Nashville, TN 37232 USA

[6] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06510 USA

[7] Yale Univ, Sch Med, Dept Neurobiol, New Haven, CT 06510 USA

来源：

JOURNAL OF NEUROSCIENCE | 2006年 / 26卷 / 41期

关键词：

hypocretin; orexin; dopamine; MCH; reinstatement; cocaine-seeking;

D O I：

10.1523/JNEUROSCI.3118-06.2006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The importance of the lateral hypothalamus in the regulation of reward and motivation has long been recognized. However, the neuronal network involved in such a hypothalamic regulation of reward remains essentially unknown. Recently, hypocretin-containing neurons, a group of hypothalamic neurons known to be associated with the stability of arousal, have emerged as important structures in the control of brain reward function. This review summarizes a Mini-Symposium presented at the 2006 Annual Meeting of the Society for Neuroscience.

引用

收藏

页码：10372 / 10375

页数：4

相关论文

共 27 条

[1] Sleep-waking discharge patterns of neurons recorded in the rat perifornical lateral hypothalamic area [J].

Alam, MN ;

Gong, H ;

Alam, T ;

Jaganath, R ;

McGinty, D ;

Szymusiak, R .

JOURNAL OF PHYSIOLOGY-LONDON, 2002, 538 (02) :619-631

[2] Orexin A in the VTA is critical for the induction of synaptic plasticity and Behavioral Sensitization to cocaine [J].

Borgland, SL ;

Taha, SA ;

Sarti, F ;

Fields, HL ;

Bonci, A .

NEURON, 2006, 49 (04) :589-601

[3] Acute and chronic cocaine-induced potentiation of synaptic strength in the ventral tegmental area: Electrophysiological and behavioral correlates in individual rats [J].

Borgland, SL ;

Malenka, RC ;

Bonci, A .

JOURNAL OF NEUROSCIENCE, 2004, 24 (34) :7482-7490

[4] Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior [J].

Boutrel, B ;

Kenny, PJ ;

Specio, SE ;

Martin-Fardon, R ;

Markou, A ;

Koob, GF ;

de Lecea, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (52) :19168-19173

[5]

Broberger C, 1998, J COMP NEUROL, V402, P460

[6] Dopaminergic regulation of orexin neurons [J].

Bubser, M ;

Fadel, JR ;

Jackson, LL ;

Meador-Woodruff, JH ;

Jing, DQ ;

Deutch, AY .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2005, 21 (11) :2993-3001

[7] Narcolepsy in orexin knockout mice:: Molecular genetics of sleep regulation [J].

Chemelli, RM ;

Willie, JT ;

Sinton, CM ;

Elmquist, JK ;

Scammell, T ;

Lee, C ;

Richardson, JA ;

Williams, SC ;

Xiong, YM ;

Kisanuki, Y ;

Fitch, TE ;

Nakazato, M ;

Hammer, RE ;

Saper, CB ;

Yanagisawa, M .

CELL, 1999, 98 (04) :437-451

[8] The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity [J].

De Lecea, L ;

Kilduff, TS ;

Peyron, C ;

Gao, XB ;

Foye, PE ;

Danielson, PE ;

Fukuhara, C ;

Battenberg, ELF ;

Gautvik, VT ;

Bartlett, FS ;

Frankel, WN ;

van den Pol, AN ;

Bloom, FE ;

Gautvik, KM ;

Sutcliffe, JG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (01) :322-327

[9] Anatomical substrates of orexin-dopamine interactions: Lateral hypothalamic projections to the ventral tegmental area [J].

Fadel, J ;

Deutch, AY .

NEUROSCIENCE, 2002, 111 (02) :379-387

[10] The hypothalamic neuropeptide melanin-concentrating hormone acts in the nucleus Accumbens to modulate feeding Behavior and forced-swim performance [J].

Georgescu, D ;

Sears, RM ;

Hommel, JD ;

Barrot, M ;

Bolaños, CA ;

Marsh, DJ ;

Bednarek, MA ;

Bibb, JA ;

Maratos-Flier, E ;

Nestler, EJ ;

DiLeone, RJ .

JOURNAL OF NEUROSCIENCE, 2005, 25 (11) :2933-2940