Genetic approaches to coronary heart disease

被引：12

作者：

Cohen, Jonathan C.

机构：

[1] Univ Texas, SW Med Ctr, Ctr Human Nutr, Dallas, TX 75390 USA

[2] Univ Texas, SW Med Ctr, McDermott Ctr Human Growth & Dev, Dallas, TX 75390 USA

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2006年 / 48卷 / 09期

关键词：

D O I：

10.1016/j.jacc.2006.06.046

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Developments in high-throughput genotyping have progressed to the point where genome-wide association studies are becoming practical. Multistage designs involving large numbers of sequence variants (similar to 300,000) and relatively large samples sizes (several hundred cases and control subjects) will be essential to reliably detect alleles with appreciable effect sizes (2-fold increase in relative risk). Direct sequencing of candidate genes in cases and control subjects provides an alternative approach that can reveal low-frequency alleles that influence disease susceptibility. Ultimately, the outcome of both approaches win depend on the genetic architecture of coronary heart disease.

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收藏

页码：A10 / A14

页数：5

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