Molecular transporters: Synthesis of oligoguanidinium transporters and their application to drug delivery and real-time imaging

被引:127
作者
Goun, Elena A.
Pillow, Thomas H.
Jones, Lisa R.
Rothbard, Jonathan B.
Wender, Paul A. [1 ]
机构
[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA
[2] Stanford Univ, Dept Mol Pharmacol, Stanford, CA 94305 USA
关键词
dendrimers; drug delivery; drug design; medicinal chemistry; peptidomimetics;
D O I
10.1002/cbic.200600171
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:1497 / 1515
页数:19
相关论文
共 98 条
[1]  
Aidley D.J., 1996, ION CHANNELS
[2]  
Atherton E., 1989, SOLID PHASE PEPTIDE
[3]   Property-based design of GPCR-targeted library [J].
Balakin, KV ;
Tkachenko, SE ;
Lang, SA ;
Okun, I ;
Ivashchenko, AA ;
Savchuk, NP .
JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES, 2002, 42 (06) :1332-1342
[4]   1H-PYRAZOLE-1-CARBOXAMIDINE HYDROCHLORIDE - AN ATTRACTIVE REAGENT FOR GUANYLATION OF AMINES AND ITS APPLICATION TO PEPTIDE-SYNTHESIS [J].
BERNATOWICZ, MS ;
WU, YL ;
MATSUEDA, GR .
JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (08) :2497-2502
[5]   Characterization of novel histidine-tagged tat-peptide complexes dual-labeled with 99mTc-tricarbonyl and fluorescein for scintigraphy and fluorescence microscopy [J].
Bullok, KE ;
Dyszlewski, M ;
Prior, JL ;
Pica, CM ;
Sharma, V ;
Piwnica-Worms, D .
BIOCONJUGATE CHEMISTRY, 2002, 13 (06) :1226-1237
[6]   Shifting foci of hematopoiesis during reconstitution from single stem cells [J].
Cao, YA ;
Wagers, AJ ;
Beilhack, A ;
Dusich, J ;
Bachmann, MH ;
Negrin, RS ;
Weissman, IL ;
Contag, CH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (01) :221-226
[7]   Molecular transporters for peptides:: delivery of a cardioprotective εPKC agonist peptide into cells and intact ischemic heart using a transport system, R7 [J].
Chen, L ;
Wright, LR ;
Chen, CH ;
Oliver, SF ;
Wender, PA ;
Mochly-Rosen, D .
CHEMISTRY & BIOLOGY, 2001, 8 (12) :1123-1129
[8]   Dendritic oligoguanidines as intracellular translocators [J].
Chung, HH ;
Harms, G ;
Seong, CM ;
Choi, BH ;
Min, CH ;
Taulane, JP ;
Goodman, M .
BIOPOLYMERS, 2004, 76 (01) :83-96
[9]  
CHUNYEN K, 2004, ADV DRUG DELIVERY RE, V56, P1143
[10]   SUBSTRATE-BINDING PROPERTIES OF FIREFLY LUCIFERASE .I. LUCIFERIN-BINDING SITE [J].
DENBURG, JL ;
LEE, RT ;
MCELROY, WD .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1969, 134 (02) :381-&