Dose-response of flurbiprofen on postoperative pain and emesis after paediatric strabismus surgery

被引:27
作者
Mikawa, K
Nishina, K
Maekawa, N
Shiga, M
Obara, H
机构
[1] Department of Anaesthesiology, Kobe University School of Medicine, Chuo-ku, Kobe 650
来源
CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE | 1997年 / 44卷 / 01期
关键词
D O I
10.1007/BF03014332
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Purpose: Intravenous flurbiprofen, a non-steroidal antiinflammatory drug (NSAID), has been used recently for postoperative pain relief in adults. The drug is also likely to have antiemetic property. The present study was undertaken to investigate the effect of flurbiprofen on postoperative pain and emesis in children undergoing strabismus surgery, which is well known to produce postoperative nausea and vomiting. Methods: In a prospective, randomised, controlled clinical trial, 90 children aged 2-11 yr received saline (control), furbiprofen 0.5 mg . kg(-1), or flurbiprofen 1 mg . kg(-1). Saline and flurbiprofen were administered iv immediately after induction of anaesthesia. Anaesthesia was induced and maintained with sevoflurane and nitrous oxide in oxygen. Postoperative pain was assessed by a blinded observed using an objective pain scale (OPS). No opioids or antiemetics were admininistered throughout the study. The incidence and frequency of vomiting were compared among groups. Results: Flurbiprofen 1 mg . kg(-1) provided lower OPS (highest) scores during the eight hours after surgery and a reduced requirement of postoperative supplementary analgesic (diclofenac suppository) compared with the other two regimens. The two doses of flurbiprofen failed to decrease the incidence and frequency of vomiting. Conclusion: These data suggest that preoperative flurbiprofen 1 mg . kg(-1) iv is a simple and effective approach to postoperative pain relief but not to the prevention of emesis following paediatric strabismus surgery.
引用
收藏
页码:95 / 98
页数:4
相关论文
共 19 条
[1]  
ALDRETE JA, 1970, ANESTH ANAL CURR RES, V49, P924
[2]   THE EFFECT OF PARACETAMOL OR DICLOFENAC ADMINISTERED BEFORE OPERATION ON POSTOPERATIVE PAIN AND BEHAVIOR AFTER ADENOIDECTOMY IN SMALL CHILDREN [J].
BAER, GA ;
RORARIUS, MGF ;
KOLEHMAINEN, S ;
SELIN, S .
ANAESTHESIA, 1992, 47 (12) :1078-1080
[3]   A COMPARISON BETWEEN BUPIVACAINE INSTILLATION VERSUS ILIOINGUINAL ILIOHYPOGASTRIC NERVE BLOCK FOR POSTOPERATIVE ANALGESIA FOLLOWING INGUINAL HERNIORRHAPHY IN CHILDREN [J].
CASEY, WF ;
RICE, LJ ;
HANNALLAH, RS ;
BROADMAN, L ;
NORDEN, JM ;
GUZZETTA, P .
ANESTHESIOLOGY, 1990, 72 (04) :637-639
[4]  
FORBES JA, 1989, PHARMACOTHERAPY, V9, P66
[5]  
France N., 1989, PEDIAT ANESTHESIA, P1065
[7]   THE EFFECTS OF ORAL DROPERIDOL VERSUS ORAL METOCLOPRAMIDE VERSUS BOTH ORAL DROPERIDOL AND METOCLOPRAMIDE ON POSTOPERATIVE VOMITING WHEN USED AS A PREMEDICANT FOR STRABISMUS SURGERY [J].
KYMER, PJ ;
BROWN, RE ;
LAWHORN, CD ;
JONES, E ;
PEARCE, L .
JOURNAL OF CLINICAL ANESTHESIA, 1995, 7 (01) :35-39
[8]   Study design in clinical research: Sample size estimation and power analysis [J].
Lerman, J .
CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE, 1996, 43 (02) :184-191
[9]  
MACLEAN D, 1983, J INT MED RES, V11, P1
[10]   ORAL CLONIDINE PREMEDICATION REDUCES VOMITING IN CHILDREN AFTER STRABISMUS SURGERY [J].
MIKAWA, K ;
NISHINA, K ;
MAEKAWA, N ;
ASANO, M ;
OBARA, H .
CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE, 1995, 42 (11) :977-981