The interferon-inducible GTPases

被引：134

作者：

Martens, Sascha

Howard, Jonathan ^{[1
]}

机构：

[1] MRC, Mol Biol Lab, Div Neurobiol, Cambridge CB2 2QH, England

[2] Univ Cologne, Inst Genet, D-5000 Cologne, Germany

来源：

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY | 2006年 / 22卷

关键词：

dynamin; Mx; guanylate-binding protein; p47; GTPase; IRG;

D O I：

10.1146/annurev.cellbio.22.010305.104619

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mammalian cells respond to interferons (IFNs) secreted during infection by the transcriptional upregulation of as many as a thousand genes. This remarkable transition prepares cells and organisms for resistance to infection, and many IFN-regulated gene products are players in well-understood resistance programs. Oddly, however, many of the most abundantly induced proteins are GTPases whose functions are not well understood. Here we review the progress that has been made toward understanding the roles of individual GTPase families in disease resistance and the hints of common mechanisms that are now available.

引用

页码：559 / 589

页数：31

共 148 条

[1] The antiviral dynamin family member, MxA, tubulates lipids and localizes to the smooth endoplasmic reticulum [J].