Evaluation of the flora of Puerto Rico for in vitro cytotoxic and anti-HIV activities

被引：4

作者：

Antoun, MD

Martinez, E

Caballero, R

Oquendo, I

Proctor, GR

Weislow, OS

McCloud, TG

Kiser, R

Staley, P

Clanton, D

机构：

[1] Univ Puerto Rico, Sch Pharm, Dept Pharmaceut Sci, San Juan, PR 00936 USA

[2] Govt Puerto Rico, Dept Nat Resources, San Juan, PR 00906 USA

[3] SRA Technol Inc, Rockville, MD USA

[4] NCI, SAIC, CRDC17, Ft Detrick, MD 21702 USA

来源：

PHARMACEUTICAL BIOLOGY | 1999年 / 37卷 / 04期

基金：

美国国家卫生研究院;

关键词：

anti-HIV activity; cytotoxicity; medicinal plants; Puerto Rico;

D O I：

10.1076/phbi.37.4.277.5805

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A total of 38 plant species belonging to 29 families were screened against HIV at the National Cancer Institute, Frederick Cancer Research and Development Center: In this assay, the virus is replicated in CEM SS cells, which are malignant cells of lymphocytic origin. It is therefore possible to measure the cytotoxicity of the extracts simultaneously, which is indicative of possible anticancer activity. Anti-MN activity was found in eight extracts, whereas 13 extracts demonstrated cytotoxicity at an IC50 of 25 mu g/ml or less.

引用

收藏

页码：277 / 280

页数：4

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