Tissue reaction to liquid silicone simulating low-grade liposarcoma following lip augmentation

We report the case of a 32-year-old woman who underwent silicone injection into the upper lip 2 years prior to presenting with masses clinically suspicious for tumor and interpreted on biopsy as low-grade liposarcoma. Lack of pre-operative history of silicone injection almost led to unnecessary surgery. This complicated situation may arise when reaction to liquid or gel silicone histologically closely simulates a low-grade liposarcoma. Clinical and pathological correlations are of critical assistance in making the correct pre-operative diagnosis and avoiding unnecessary traumatic surgical intervention.