Speed congenics: a classic technique in the fast lane (relatively speaking)

被引：249

作者：

Wakeland, E ^{[1
]}

Morel, L ^{[1
]}

Achey, K ^{[1
]}

Yui, M ^{[1
]}

Longmate, J ^{[1
]}

机构：

[1] CITY HOPE NATL MED CTR,DEPT BIOSTAT,DUARTE,CA 91019

来源：

IMMUNOLOGY TODAY | 1997年 / 18卷 / 10期

关键词：

D O I：

10.1016/S0167-5699(97)01126-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Marker-assisted selection protocol (MASP)-based strategies produce congenic strains with the target gene contained on clearly defined donor-derived genomic intervals in less than half the number of generations required by the classic protocol. Thus, the quality and speed of congenic strain construction are enhanced by this methodology. Here, Edward Wakeland and colleagues compare various MASP-based strategies and discuss their advantages with reference to immunological traits.

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页码：472 / 477

页数：6

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