Novel linear polyene antibiotics: Linearmycins

被引：20

作者：

Sakuda, S ^{[1
]}

GuceBigol, U ^{[1
]}

Itoh, M ^{[1
]}

Nishimura, T ^{[1
]}

Yamada, Y ^{[1
]}

机构：

[1] OSAKA UNIV,FAC ENGN,DEPT BIOTECHNOL,SUITA,OSAKA 565,JAPAN

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1996年 / 18期

关键词：

D O I：

10.1039/p19960002315

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

Two novel linear polyene antibiotics, termed linearmycin A1 and B2, have been isolated from the mycelial extracts of Streptomyces sp.no.30 and characterized as compounds 1 and 2, respectively, These compounds have similar, long linear structures terminating with amino and carboxylic acid groups, and show antifungal and antibacterial activity, The incorporation experiments using C-13-labelled acetate and propionate suggest that 1 is biosynthesized from one gamma-aminobutyric acid, 24 acetate and 4 propionate molecules, by a polyketide pathway.

引用

页码：2315 / 2319

页数：5

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