Studies towards the taxane ring system via a cascade macrocyclisation-transannulation strategy

被引：6

作者：

Houldsworth, SJ ^{[1
]}

Pattenden, G ^{[1
]}

Pryde, DC ^{[1
]}

Thomson, NM ^{[1
]}

机构：

[1] UNIV NOTTINGHAM,DEPT CHEM,NOTTINGHAM NG7 2RD,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1997年 / 08期

关键词：

D O I：

10.1039/a700784a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of the omega-iodoacetylene 6 with Bu3SnH-AIBN produces the taxane ring system 9 (45-60%) by way of transannular cyclisation from the macrocyclic vinyl radical intermediate 8, whereas the analogous iodoacetylenes 5a, 11 and 13a, together with the iodopolyenones 12a, 14a and 17, failed to give corresponding taxane systems, i.e. 7, 16 and 19 on similar treatment; instead only products resulting from direct reduction of the carbon-iodine bonds in these substrates were obtained.

引用

页码：1091 / 1093

页数：3

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