Dealing with competing risks: testing covariates and calculating sample size

被引：45

作者：

Pintilie, M ^{[1
]}

机构：

[1] Princess Margaret Hosp, Ontario Canc Inst, Dept Biostat, Toronto, ON M5G 2M9, Canada

来源：

STATISTICS IN MEDICINE | 2002年 / 21卷 / 22期

关键词：

competing risks; sample size; power; Cox proportional hazards model;

D O I：

10.1002/sim.1271

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

It is universally agreed that Kaplan-Meier estimates overestimate the probability of the event of interest in the presence of competing risks. Kalbfleisch and Prentice recommend using the cumulative incidence as an estimate of the probability of an event of interest. However, there is no consensus on how to test the effect of a covariate in the presence of competing risks. Using simulations, this paper illustrates that the Cox proportional hazards model gives valid results when employed in testing the effect of a covariate on the hazard rate and when estimating the hazard ratio. A method to calculate the sample size for testing the effect of a covariate on outcome in the presence of competing risks is also provided. Copyright (C) 2002 John Wiley Sons, Ltd.

引用

页码：3317 / 3324

页数：8

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