Analogous cytokine responses to Burkholderia pseudomallei strains contrasting in virulence correlate with partial cross-protection in immunized mice

被引：13

作者：

Ulett, GC

Ketheesan, N

Clair, TW

McElnea, CL

Barnes, JL

Hirst, RG

机构：

[1] James Cook Univ N Queensland, Dept Microbiol & Immunol, Townsville, Qld 4811, Australia

[2] James Cook Univ N Queensland, Sch Med, Townsville, Qld 4811, Australia

来源：

INFECTION AND IMMUNITY | 2002年 / 70卷 / 07期

关键词：

D O I：

10.1128/IAI.70.7.3953-3958.2002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cytokine mRNA levels were assessed in Burkholderia pseudomallei-suseeptible BALB/c mice and B. pseudomallei-resistant C57BL/6 mice following administration of a sublethal dose of less virulent (LV) B. pseudomallei, a candidate immunogen tested for protection against a highly virulent (HV) challenge. Compared on the basis of the bacterial loads, the cytokine patterns induced by RV and LV B. pseudomallei were similar, involving gamma interferon, interleukin-10, and other cytokines. Partial cross-protection between B. pseudomallei strains is shown to be associated with cytokine profiles involving both type 1 and type 2 cytokines.

引用

收藏

页码：3953 / 3958

页数：6

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