Dual function glutamate-related ligands: Discovery of a novel, potent inhibitor of glutamate carboxypeptidase II possessing mGluR3 agonist activity

被引：54

作者：

Nan, F

Bzdega, T

Pshenichkin, S

Wroblewski, JT

Wroblewska, B

Neale, JH

Kozikowski, AP

机构：

[1] Georgetown Univ, Med Ctr, Georgetown Inst Cognit & Computat Sci, Drug Discovery Program, Washington, DC 20007 USA

[2] Georgetown Univ, Med Ctr, Dept Pharmacol, Washington, DC 20007 USA

[3] Georgetown Univ, Med Ctr, Dept Biol, Washington, DC 20007 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2000年 / 43卷 / 05期

关键词：

D O I：

10.1021/jm9905559

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：772 / 774

页数：3

共 28 条

[1]

Bzdega T, 1997, J NEUROCHEM, V69, P2270

[2] The nagging question of the function of N-acetylaspartylglutamate [J].

Coyle, JT .

NEUROBIOLOGY OF DISEASE, 1997, 4 (3-4) :231-238

[3] N-ACETYLASPARTYLGLUTAMATE - POSSIBLE ROLE AS THE NEUROTRANSMITTER OF THE LATERAL OLFACTORY TRACT [J].

FFRENCHMULLEN, JMH ;

KOLLER, K ;

ZACZEK, R ;

COYLE, JT ;

HORI, N ;

CARPENTER, DO .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (11) :3897-3900

[4] Design, synthesis, and biological activity of a potent inhibitor of the neuropeptidase N-acetylated alpha-linked acidic dipeptidase [J].

Jackson, PF ;

Cole, DC ;

Slusher, BS ;

Stetz, SL ;

Ross, LE ;

Donzanti, BA ;

Trainor, DA .

JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (02) :619-622

[5] LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors [J].

Kingston, AE ;

Ornstein, PL ;

Wright, RA ;

Johnson, BG ;

Mayne, NG ;

Burnett, JP ;

Belagaje, R ;

Wu, S ;

Schoepp, DD .

NEUROPHARMACOLOGY, 1998, 37 (01) :1-12

[6] METABOTROPIC GLUTAMATE RECEPTORS : NOVEL TARGETS FOR DRUG DEVELOPMENT [J].

KNOEPFEL, T ;

KUHN, R ;

ALLGEIER, H .

JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (09) :1417-1426

[7] Synthesis and biology of the conformationally restricted ACPD analogue, 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I, a potent mGluR agonist [J].

Kozikowski, AP ;

Steensma, D ;

Araldi, GL ;

Tückmantel, W ;

Wang, SM ;

Pshenichkin, S ;

Surina, E ;

Wroblewski, JT .

JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (10) :1641-1650

[8]

Luthi-Carter R, 1998, J PHARMACOL EXP THER, V286, P1020

[9]

MOFFETT RB, 1963, ORG SYNTH, V4, P652

[10] MOLECULAR DIVERSITY OF GLUTAMATE RECEPTORS AND IMPLICATIONS FOR BRAIN-FUNCTION [J].

NAKANISHI, S .

SCIENCE, 1992, 258 (5082) :597-603

← 1 2 3 →