Comparison of intramuscular and footpad subcutaneous immunization with DNA vaccine encoding HSV-gD2 in mice

被引：12

作者：

Jazayeri, Mohammad ^{[1
]}

Soleimanjahi, Hoorieh ^{[1
]}

Fotouhi, Fatemeh ^{[1
]}

Pakravan, Nafiseh ^{[2
]}

机构：

[1] Tarbiat Modares Univ, Dept Virol, Fac Med Sci, Tehran, Iran

[2] Tarbiat Modares Univ, Dept Immunol, Fac Med Sci, Tehran, Iran

来源：

COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES | 2009年 / 32卷 / 05期

关键词：

DNA vaccine; Herpes simplex virus type 2; Glycoprotein D; Intramuscular; Footpad; ANTIGEN-SPECIFIC ANTIBODY; IMMUNE-RESPONSES; INDUCTION; ROUTE;

D O I：

10.1016/j.cimid.2008.05.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Herpes simplex virus type 2 is the most common infectious agent in humans that causes genital herpes disease and vaccination is a desirable method to prevent herpes infections. An effective therapeutic vaccine will need to elicit virus-specific immune responses. The route of immunization has important role in immune responses. In this study, DNA vaccine encoding glycoprotein D of herpes simplex virus type 2 (HSV-gD2) was prepared and injected via intramuscular and footpad routes to determine the optimal method of delivery for immune stimulation. The control manipulation of immune response by concerning route of administration is highly appreciated issue by researches. Although DNA vaccine containing HSV-gD2 is effective in both intramuscular and footpad injection routes, the latter could induce significantly higher cellular responses against HSV-2. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：453 / 461

页数：9

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