The effects of local platelet rich plasma delivery on diabetic fracture healing

被引：126

作者：

Gandhi, A

Dumas, C

O'Connor, JP

Parsons, JR

Lin, SS

机构：

[1] Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Orthopaed, Newark, NJ 07103 USA

[2] New Jersey Inst Technol, Dept Biomed Engn, Newark, NJ 07102 USA

来源：

BONE | 2006年 / 38卷 / 04期

关键词：

diabetes mellitus; fracture; BB Wistar rat; platelet rich plasma; growth factors;

D O I：

10.1016/j.bone.2005.10.019

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Several Studies have documented that diabetes impairs bone healing clinically and experimentally. The percutaneous delivery of platelet rich plasma (PRP) was used in the diabetic BB Wistar femur fracture model to investigate the use of PRP as a concentrated source of critical early growth factors on bone healing. PRP delivery at the fracture site normalized the early (cellular proliferation and chondrogenesis) parameters while improving the late (mechanical strength) parameters of diabetic fracture healing. These results Suggest a role for PRP in mediating diabetic fracture healing and potentially other high risk fractures. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：540 / 546

页数：7

共 61 条

[1] Evaluation of platelet-rich plasma in combination with freeze-dried bone in the rabbit cranium - A pilot study [J].