Reduction of left ventricular hypertrophy after exercise and weight loss in overweight patients with mild hypertension

被引:74
作者
Hinderliter, A
Sherwood, A
Gullette, ECD
Babyak, M
Waugh, R
Georgiades, A
Blumenthal, JA
机构
[1] Univ N Carolina, Div Cardiol, Dept Med, Chapel Hill, NC 27599 USA
[2] Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC USA
[3] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA
关键词
D O I
10.1001/archinte.162.12.1333
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Hypertrophy and concentric remodeling of the left ventricle are important manifestations of hypertension that are associated with increased morbidity and mortality. Although lifestyle interventions are efficacious in lowering blood pressure, evidence that they have a beneficial effect on target organs has been lacking. Objective: To assess the effects of regular aerobic exercise or exercise plus weight management counseling on left ventricular mass and geometry in overweight, sedentary men and women with high-normal or mildly elevated blood pressure. Methods: Eighty-two participants in a randomized, controlled trial were assigned to supervised aerobic exercise only, a behavioral weight management program that included exercise, or a waiting-list control group for 6 months. Blood pressure and echo cardiographic measures of left ventricular structure were measured at baseline and at the conclusion of the treatment phase. Results: The 45 women and 37 men had a mean +/- SD age of 47 +/- 9 years and had a mean SD blood pressure of 140 +/- 10/93 +/- 5 mm Hg. Blood pressure fell by 7/6 mm Hg in the weight management group and by 3/4 mm Hg in the aerobic exercise group. In association with these decreases in blood pressure, participants in the intervention groups exhibited significant decreases in left ventricular relative wall thickness (P=.003), posterior wall thickness (P=.05), and septal thickness (P=.004) and a trend toward a decrease in indexed left ventricular mass (P=.08) relative to the control group. Conclusions: In a cohort of overweight, sedentary men and women, exercise and weight loss reduced blood pressure and induced favorable changes in left ventricular structure.
引用
收藏
页码:1333 / 1339
页数:7
相关论文
共 33 条
[1]   EFFECT OF WEIGHT-LOSS ON LEFT-VENTRICULAR MASS IN NONHYPERTENSIVE MORBIDLY OBESE PATIENTS [J].
ALPERT, MA ;
LAMBERT, CR ;
TERRY, BE ;
KELLY, DL ;
PANAYIOTOU, H ;
MUKERJI, V ;
MASSEY, CV ;
COHEN, MV .
AMERICAN JOURNAL OF CARDIOLOGY, 1994, 73 (12) :918-921
[2]  
[Anonymous], 1997, ARCH INTERN MED, V157, P2413, DOI DOI 10.1001/ARCHINTE.1997.00440420033005
[3]   EFFECT OF MODERATE PHYSICAL-TRAINING ON LEFT-VENTRICULAR MASS IN MILD HYPERTENSIVE PERSONS [J].
BAGLIVO, HP ;
FABREGUES, G ;
BURRIEZA, H ;
ESPER, RC ;
TALARICO, M ;
ESPER, RJ .
HYPERTENSION, 1990, 15 (02) :I153-I156
[4]   COMPARISON OF HIGH-INTENSITY AND LOW-INTENSITY EXERCISE TRAINING EARLY AFTER ACUTE MYOCARDIAL-INFARCTION [J].
BLUMENTHAL, JA ;
REJESKI, WJ ;
WALSHRIDDLE, M ;
EMERY, CF ;
MILLER, H ;
ROARK, S ;
RIBISL, PM ;
MORRIS, PB ;
BRUBAKER, P ;
WILLIAMS, RS .
AMERICAN JOURNAL OF CARDIOLOGY, 1988, 61 (01) :26-30
[5]   Exercise and weight loss reduce blood pressure in men and women with mild hypertension - Effects on cardiovascular, metabolic, and hemodynamic functioning [J].
Blumenthal, JA ;
Sherwood, A ;
Gullette, ECD ;
Babyak, M ;
Waugh, R ;
Georgiades, A ;
Craighead, LW ;
Tweedy, D ;
Feinglos, M ;
Appelbaum, M ;
Hayano, J ;
Hinderliter, A .
ARCHIVES OF INTERNAL MEDICINE, 2000, 160 (13) :1947-1958
[6]  
Brownell K.D., 1994, LEARN PROGRAM WEIGHT, V6th
[7]   VALUE OF ECHOCARDIOGRAPHIC MEASUREMENT OF LEFT-VENTRICULAR MASS IN PREDICTING CARDIOVASCULAR MORBID EVENTS IN HYPERTENSIVE MEN [J].
CASALE, PN ;
DEVEREUX, RB ;
MILNER, M ;
ZULLO, G ;
HARSHFIELD, GA ;
PICKERING, TG ;
LARAGH, JH .
ANNALS OF INTERNAL MEDICINE, 1986, 105 (02) :173-178
[8]  
Chalmers J, 1999, J HYPERTENS, V17, P151
[9]   RELATION OF OBESITY AND GENDER TO LEFT-VENTRICULAR HYPERTROPHY IN NORMOTENSIVE AND HYPERTENSIVE ADULTS [J].
DESIMONE, G ;
DEVEREUX, RB ;
ROMAN, MJ ;
ALDERMAN, MH ;
LARAGH, JH .
HYPERTENSION, 1994, 23 (05) :600-606
[10]   LEFT-VENTRICULAR MASS AND BODY SIZE IN NORMOTENSIVE CHILDREN AND ADULTS - ASSESSMENT OF ALLOMETRIC RELATIONS AND IMPACT OF OVERWEIGHT [J].
DESIMONE, G ;
DANIELS, SR ;
DEVEREUX, RB ;
MEYER, RA ;
ROMAN, MJ ;
DEDIVITIIS, O ;
ALDERMAN, MH .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1992, 20 (05) :1251-1260