Sulfamidation of 2-arylaldehydes and ketones with chloramine-T

被引：31

作者：

Baumann, Thomas ^{[1
]}

Baechle, Michael ^{[1
]}

Braese, Stefan ^{[1
]}

机构：

[1] Univ Karlsruhe, Inst Organ Chem, TH, D-76131 Karlsruhe, Germany

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 17期

关键词：

D O I：

10.1021/ol061410g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of aliphatic and aromatic carbonyl compounds has been transformed into the corresponding sulfamidated products by means of amine-catalyzed nitrene transfer of chloramine-T. Depending on the residues R, either alpha-sulfamidation in the case of aromatic aldehydes and acetone derivatives or direct sulfamidation at the carbonyl functionality of aliphatic aldehydes has been observed. Applying microwave conditions, good to excellent yields under significantly reduced reaction times could be obtained, thus providing a facile access to alpha, alpha-disubstituted amino acids.

引用

页码：3797 / 3800

页数：4

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