Synthesis of the 4-arylindole portion of the antitumor agent diazonamide and related studies

被引：38

作者：

Chan, F ^{[1
]}

Magnus, P ^{[1
]}

McIver, EG ^{[1
]}

机构：

[1] Univ Texas, Dept Chem & Biochem, Austin, TX 78712 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(99)02204-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of 6 comprising the CDG rings of the diazonamides was achieved in an overall yield of 75% from commercially available 3. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：835 / 838

页数：4

相关论文

共 18 条

[1] [Anonymous], [No title captured], Patent No. 3976639
[2] Heteroatom- and carbon-linked biphenyl analogs of brequinar as immunosuppressive agents
Batt, DG
Petraitis, JJ
Sherk, SR
Copeland, RA
Dowling, RL
Taylor, TL
Jones, EA
Magolda, RL
Jaffee, BD
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1998, 8 (13) : 1745 - 1750
[3] EFFICIENT SYNTHESIS OF 2-CHLOROINDOLE, 2-BROMOINDOLE, AND 2-IODOINDOLE
BERGMAN, J
VENEMALM, L
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (08) : 2495 - 2497
[4] Cyclization of N-acylanthranilic acids with Vilsmeier reagents. Chemical and structural studies
Bergman, J
Stalhandske, C
[J]. TETRAHEDRON, 1996, 52 (03) : 753 - 770
[5] REACTION OF INDOLE AND INDOLE GRIGNARD-REAGENT WITH PHOSGENE - FACILE SYNTHESIS OF INDOLE-3-CARBOXYLIC ACID-DERIVATIVES
BERGMAN, J
CARLSSON, R
SJOBERG, B
[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1977, 14 (07) : 1123 - 1134
[6] A synthetic approach towards the aromatic macrocyclic core of diazonamide A based on sp2-sp2 coupling protocols
Boto, A
Ling, M
Meek, G
Pattenden, G
[J]. TETRAHEDRON LETTERS, 1998, 39 (44) : 8167 - 8170
[7] CLARK RD, 1984, HETEROCYCLES, V22, P195
[8] HASE TA, 1979, TETRAHEDRON LETT, P2633
[9] Konopelski JP, 1996, SYNLETT, P609
[10] SYNTHETIC STUDIES IN THE INDOLE SERIES - PREPARATION OF THE UNIQUE ANTIBIOTIC ALKALOID CHUANGXINMYCIN BY A NITRO-GROUP DISPLACEMENT REACTION
KOZIKOWSKI, AP
GRECO, MN
SPRINGER, JP
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1982, 104 (26) : 7622 - 7626