A Supramolecular Polymer as a Self-Assembling Polyvalent Scaffold

被引：111

作者：

Mueller, Marion K. ^{[2
,3
]}

Brunsveld, Luc ^{[1
,2
,3
]}

机构：

[1] TU Eindhoven, Dept Biomed Engn, Biol Chem Lab, Eindhoven, Netherlands

[2] Max Planck Inst Mol Physiol, Dept Biol Chem, D-44227 Dortmund, Germany

[3] Chem Genom Ctr, D-44227 Dortmund, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 16期

关键词：

carbohydrates; fluorescence; polyvalency; self-assembly; supramolecular polymers; CONCANAVALIN-A; TERMINAL ALKYNES; BINDING; LIGANDS; LECTIN; AZIDES; THERMODYNAMICS; AMPLIFICATION; GALECTIN-1; NANOFIBERS;

D O I：

10.1002/anie.200900143

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Binding bacteria: Discotic molecules self-assemble into columnar supramolecular polymers that show strong polyvalent binding to bacteria by virtue of mannose ligands attached at their periphery (orange; see picture). The reversible formation of the supramolecular polymers allows simple mixing of differently substituted monomers and the optimization of bacterial aggregation. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2921 / 2924

页数：4

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