Vascular endothelial cells synthesize and secrete brain-derived neurotrophic factor

被引：391

作者：

Nakahashi, T ^{[1
]}

Fujimura, H ^{[1
]}

Altar, CA ^{[1
]}

Li, J ^{[1
]}

Kambayashi, J ^{[1
]}

Tandon, NN ^{[1
]}

Sun, B ^{[1
]}

机构：

[1] Otsuka Amer Pharmaceut Inc, Maryland Res Labs, Rockville, MD 20850 USA

来源：

FEBS LETTERS | 2000年 / 470卷 / 02期

关键词：

neurotrophin; human umbilical vein endothelial cell; cAMP; platelet;

D O I：

10.1016/S0014-5793(00)01302-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Brain-derived neurotrophic factor (BDNF) is an abundant neurotrophin in brain and peripheral nerves, where it affects neural development, survival and repair after injury, BDNF has been detected in rat and human blood, but the source of circulating BDNF is not established, BDNF messenger and peptide were detected in cultured cells and in the culture medium of human umbilical vein endothelial cells, The expression of BDNF was up-regulated by elevation of intracellular cAMP and down-regulated by Ca2+ ionophore, bovine brain extract and laminar fluid shear stress. These results suggest that vascular endothelial cells may contribute to circulating BDNF. (C) 2000 Federation of European Biochemical Societies.

引用

页码：113 / 117

页数：5

共 30 条

[1]

BARDE Y-A, 1990, Progress in Growth Factor Research, V2, P237, DOI 10.1016/0955-2235(90)90021-B

[2] REGULATION OF NERVE GROWTH-FACTOR MESSENGER-RNA LEVELS IN DEVELOPING RAT-HEART VENTRICLE IS NOT ALTERED BY SYMPATHECTOMY [J].

CLEGG, DO ;

LARGE, TH ;

BODARY, SC ;

REICHARDT, LF .

DEVELOPMENTAL BIOLOGY, 1989, 134 (01) :30-37

[3] FLOW-MEDIATED ENDOTHELIAL MECHANOTRANSDUCTION [J].

DAVIES, PF .

PHYSIOLOGICAL REVIEWS, 1995, 75 (03) :519-560

[4]

DONOVAN MJ, 1995, AM J PATHOL, V147, P309

[5] CREB: A major mediator of neuronal neurotrophin responses [J].

Finkbeiner, S ;

Tavazoie, SF ;

Maloratsky, A ;

Jacobs, KM ;

Harris, KM ;

Greenberg, ME .

NEURON, 1997, 19 (05) :1031-1047

[6] SHEAR-DEPENDENT THICKENING OF THE HUMAN ARTERIAL INTIMA [J].

FRIEDMAN, MH ;

DETERS, OJ ;

BARGERON, CB ;

HUTCHINS, GM ;

MARK, FF .

ATHEROSCLEROSIS, 1986, 60 (02) :161-171

[7]

Fujimura H, 1999, THROMB HAEMOSTASIS, P513

[8]

GRABER N, 1990, J IMMUNOL, V145, P819

[9] Localization of neurotrophins and their high-affinity receptors during human enteric nervous system development [J].

Hoehner, JC ;

Wester, T ;

Pahlman, S ;

Olsen, L .

GASTROENTEROLOGY, 1996, 110 (03) :756-767

[10] IDENTIFICATION AND CHARACTERIZATION OF A NOVEL MEMBER OF THE NERVE GROWTH-FACTOR BRAIN-DERIVED NEUROTROPHIC FACTOR FAMILY [J].

HOHN, A ;

LEIBROCK, J ;

BAILEY, K ;

BARDE, YA .

NATURE, 1990, 344 (6264) :339-341

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