Roles of peroxisome proliferator-activated receptor γ in lipid homeostasis and inflammatory responses of macrophages

被引：27

作者：

Klappacher, GW

Glass, CK

机构：

[1] Univ Calif San Diego, Dept Cellular & Mol Med, La Jolla, CA 92093 USA

[2] Univ Vienna, Dept Cardiol, Vienna, Austria

来源：

CURRENT OPINION IN LIPIDOLOGY | 2002年 / 13卷 / 03期

关键词：

D O I：

10.1097/00041433-200206000-00011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Monocytes play a critical role in atherogenesis by their inflammatory signals and differentiation into macrophage foam cells through cholesterol accumulation. The seminal finding of high levels of the peroxisome proliferator-activated receptor gamma in macrophage foam cells has opened up the prospect that its ligands, most importantly the thiazolidinedione class of drugs, might directly influence the development of atheromatous lesions. The present review weighs the growing evidence on regulation of both inflammatory responses and cholesterol homeostasis in macrophages by peroxisome proliferator-activated receptor gamma ligands with regard to their overall impact as antiatherogenic agents. Curr Opin Lipidol 13:305-312. (C) 2002 Lippincott Williams Wilkins.

引用

页码：305 / 312

页数：8

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