Mirror Image of the Amyloid-β Species in Cerebrospinal Fluid and Cerebral Amyloid in Alzheimer's Disease

被引：10

作者：

Catania, Marcella ^{[1
]}

Di Fede, Giuseppe ^{[1
]}

Tonoli, Elisa ^{[2
]}

Benussi, Luisa ^{[2
]}

Pasquali, Claudio ^{[1
]}

Giaccone, Giorgio ^{[1
]}

Maderna, Emanuela ^{[1
]}

Ghidoni, Roberta ^{[2
]}

Tagliavini, Fabrizio ^{[1
]}

机构：

[1] IRCCS Fdn, Carlo Besta Neurol Inst, Div Neurol & Neuropathol 5, I-20133 Milan, Italy

[2] IRCCS Ist Ctr San Giovanni di Dio Fatebenefratell, Mol Markers Lab, Brescia, Italy

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2015年 / 47卷 / 04期

关键词：

Alzheimer's disease; amyloid-beta; biomarker; cerebrospinal fluid; SELDI-TOF MS; PEPTIDE; MUTATION; PROTEIN; WATER; GENE;

D O I：

10.3233/JAD-150179

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alzheimer's disease (AD) is characterized by amyloid-beta (A beta) accumulation in brain that is paralleled by A beta(1-42) reduction in cerebrospinal fluid (CSF). We analyzed the pattern of A beta peptides, including the N- and C-terminal truncated fragments, in brain and CSF from two familial and one sporadic AD cases. We found that (i) each patient is characterized by a distinct A beta profile in CSF and brain deposits and (ii) the CSF A beta pattern mirrors the A beta profile of cerebral amyloid. These results suggest the existence of different molecular AD subtypes which can be recognized by CSF analysis, enabling patient stratification.

引用

页码：877 / 881

页数：5

共 21 条

[1] Optimization protocol for amyloid-β peptides detection in human cerebrospinal fluid using SELDI TOF MS
Albertini, Valentina
Bruno, Anna
Paterlini, Anna
Lista, Simone
Benussi, Luisa
Cereda, Cristina
Binetti, Giuliano
Ghidoni, Roberta
[J]. PROTEOMICS CLINICAL APPLICATIONS, 2010, 4 (03) : 352 - 357
[2] CSF markers for incipient Alzheimer's disease
Blennow, K
Hampel, H
[J]. LANCET NEUROLOGY, 2003, 2 (10) : 605 - 613
[3] Good gene, bad gene: New APP variant may be both
Di Fede, Giuseppe
Catania, Marcella
Morbin, Michela
Giaccone, Giorgio
Moro, Maria Luisa
Ghidoni, Roberta
Colombo, Laura
Messa, Massimo
Cagnotto, Alfredo
Romeo, Margherita
Stravalaci, Matteo
Diomede, Luisa
Gobbi, Marco
Salmona, Mario
Tagliavini, Fabrizio
[J]. PROGRESS IN NEUROBIOLOGY, 2012, 99 (03) : 281 - 292
[4] A Recessive Mutation in the APP Gene with Dominant-Negative Effect on Amyloidogenesis
Di Fede, Giuseppe
Catania, Marcella
Morbin, Michela
Rossi, Giacomina
Suardi, Silvia
Mazzoleni, Giulia
Merlin, Marco
Giovagnoli, Anna Rita
Prioni, Sara
Erbetta, Alessandra
Falcone, Chiara
Gobbi, Marco
Colombo, Laura
Bastone, Antonio
Beeg, Marten
Manzoni, Claudia
Francescucci, Bruna
Spagnoli, Alberto
Cantu, Laura
Del Favero, Elena
Levy, Efrat
Salmona, Mario
Tagliavini, Fabrizio
[J]. SCIENCE, 2009, 323 (5920) : 1473 - 1477
[5] Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Aβ42 in humans
Fagan, AM
Mintun, MA
Mach, RH
Lee, SY
Dence, CS
Shah, AR
LaRossa, GN
Spinner, ML
Klunk, WE
Mathis, CA
DeKosky, ST
Morris, JC
Holtzman, DM
[J]. ANNALS OF NEUROLOGY, 2006, 59 (03) : 512 - 519
[6] A Window into the Heterogeneity of Human Cerebrospinal Fluid Aβ Peptides
Ghidoni, Roberta
Paterlini, Anna
Albertini, Valentina
Stoppani, Elena
Binetti, Giuliano
Fuxe, Kjell
Benussi, Luisa
Agnati, Luigi F.
[J]. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2011,
[7] Novel T719P AβPP Mutation Unbalances the Relative Proportion of Amyloid-β Peptides
Ghidoni, Roberta
Albertini, Valentina
Squitti, Rosanna
Paterlini, Anna
Bruno, Anna
Bernardini, Silvia
Cassetta, Emanuele
Rossini, Paolo Maria
Squitieri, Ferdinando
Benussi, Luisa
Binetti, Giuliano
[J]. JOURNAL OF ALZHEIMERS DISEASE, 2009, 18 (02) : 295 - 303
[8] Neuropathology of the recessive A673V APP mutation: Alzheimer disease with distinctive features
Giaccone, Giorgio
Morbin, Michela
Moda, Fabio
Botta, Mario
Mazzoleni, Giulia
Uggetti, Andrea
Catania, Marcella
Moro, Maria Luisa
Redaelli, Veronica
Spagnoli, Alberto
Rossi, Roberta Simona
Salmona, Mario
Di Fede, Giuseppe
Tagliavini, Fabrizio
[J]. ACTA NEUROPATHOLOGICA, 2010, 120 (06) : 803 - 812
[9] AMYLOID BETA-PEPTIDE IS PRODUCED BY CULTURED-CELLS DURING NORMAL METABOLISM
HAASS, C
SCHLOSSMACHER, MG
HUNG, AY
VIGOPELFREY, C
MELLON, A
OSTASZEWSKI, BL
LIEBERBURG, I
KOO, EH
SCHENK, D
TEPLOW, DB
SELKOE, DJ
[J]. NATURE, 1992, 359 (6393) : 322 - 325
[10] Medicine - The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
Hardy, J
Selkoe, DJ
[J]. SCIENCE, 2002, 297 (5580) : 353 - 356

← 1 2 3 →