Molecular mechanisms of lacrimal acinar secretory vesicle exocytosis

被引：40

作者：

Wu, Kaijin

Jerdeva, Galina V.

da Costa, Silvia R.

Sou, Eunbyul

Schechter, Joel E.

Hamm-Alvarez, Sarah F.

机构：

[1] Univ So Calif, Sch Pharm, Dept Pharmaceut Sci, Los Angeles, CA 90033 USA

[2] Univ So Calif, Dept Cell & Neurobiol, Los Angeles, CA 90033 USA

[3] Univ So Calif, Dept Physiol & Biophys, Los Angeles, CA 90033 USA

[4] Univ So Calif, Dept Ophthalmol, Los Angeles, CA 90032 USA

来源：

EXPERIMENTAL EYE RESEARCH | 2006年 / 83卷 / 01期

关键词：

exocytosis; rab3D; VAMP2; actin filaments; microtubules; cytoplasmic dynein; non-muscle myosin II; NOD mouse; Sjogren's syndrome;

D O I：

10.1016/j.exer.2005.11.009

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

The acinar epithelial cells of the lacrimal gland are responsible for the production, packaging and regulated exocytosis of tear proteins into ocular surface fluid. This review summarizes new findings on the mechanisms of exocytosis in these cells. Participating proteins are discussed within the context of different categories of trafficking effectors including targeting and specificity factors (rabs, SNAREs) and transport factors (microtubules, actin filaments and motor proteins). Recent information describing fundamental changes in basic exocytotic mechanisms in the NOD mouse, an animal model of Sjogren's syndrome, is presented. (c) 2006 Elsevier Ltd. All rights reserved.

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页码：84 / 96

页数：13

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