Human aryl hydrocarbon receptor nuclear translocator gene (ARNT) D/N511 polymorphism

被引：15

作者：

Cao, HN ^{[1
]}

Hegele, RA ^{[1
]}

机构：

[1] John P Robarts Res Inst, Blackburn Cardiovasc Genet Lab, London, ON N6A 5K8, Canada

来源：

JOURNAL OF HUMAN GENETICS | 2000年 / 45卷 / 02期

关键词：

pharmacogenetics; xenobiotics; cytochrome p450; lipodystrophy;

D O I：

10.1007/s100380050018

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We found a novel A --> C change in codon 511 of the ARNT gene, which predicted the substitution of Asn (AAC) for Asp (GAC) at this position. Amplification using mismatched primers allowed the ARNT D/N511 polymorphism to be detected by digestion with endonuclease Tth111I. The frequency of the ARNT N511 allele was 0.019 in Caucasians and 0.026 in Africans. Because of the importance of the ARNT gene product in the metabolism of xenobiotics, this polymorphism may be useful in the study of associations with metabolic phenotypes and in pharmacogenetic studies.

引用

页码：92 / 93

页数：2

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