A short synthesis of bicyclic dipeptides corresponding to Xxx-L-pro Xxx-D-pro having constrained trans-proline amides

被引：23

作者：

Curran, TP ^{[1
]}

Marcaurelle, LA ^{[1
]}

O'Sullivan, KM ^{[1
]}

机构：

[1] Coll Holy Cross, Dept Chem, Worcester, MA 01610 USA

来源：

ORGANIC LETTERS | 1999年 / 1卷 / 08期

关键词：

D O I：

10.1021/ol9902069

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A short synthesis that generates two isomeric bicyclic dipeptides having constrained, trans-proline amide bonds has been developed. One of these bicyclic dipeptides corresponds to an Xxx-L-Pro dipeptide (4), while the other isomer corresponds to an Xxx-D-Pro dipeptide (5). The two isomers are readily distinguished by their H-1 NMR spectra.

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页码：1225 / 1228

页数：4

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