Vitamin D action and regulation of bone remodeling: Suppression of osteoclastogenesis by the mature osteoblast

被引：126

作者：

Baldock, Paul A.

Thomas, Gethin P.

Hodge, Jason M.

Baker, Sara U. K.

Dressel, Uwe

O'Loughlin, Peter D.

Nicholson, Geoffrey C.

Briffa, Kathy H.

Eisman, John A.

Gardiner, Edith M.

机构：

[1] St Vincent Hosp, Garvan Inst Med Res, Bone Res Program, Sydney, NSW, Australia

[2] Univ Melbourne, Dept Clin & Biomed Sci, Geelong, Vic, Australia

[3] Inst Med & Vet Sci, Dept Clin Biochem, Adelaide, SA 5000, Australia

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2006年 / 21卷 / 10期

关键词：

vitamin D; osteoclastogenesis; mature osteoblast; osteoprotegerin;

D O I：

10.1359/JBMR.060714

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Vitamin D acts through the immature osteoblast to stimulate osteoclastogenesis. Transgenic elevation of VDR in mature osteoblasts was found to inhibit osteoclastogenesis associated with an altered OPG response. This inhibition was confined to cancellous bone. This study indicates that vitamin D-mediated osteoclastogenesis is regulated locally by OPG production in the mature osteoblast.

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收藏

页码：1618 / 1626

页数：9

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