Targeting sphingosine-I-phosphate for cancer therapy

被引：55

作者：

Sabbadini, R. A.

机构：

[1] San Diego State Univ, Dept Biol, San Diego, CA 92182 USA

[2] Lpath Inc, San Diego, CA 92182 USA

来源：

BRITISH JOURNAL OF CANCER | 2006年 / 95卷 / 09期

关键词：

tumour microenvironment; bioactive lipid signaling; sphingosine-I-phosphate; lipodomics; angiogenisis;

D O I：

10.1038/sj.bjc.6603400

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This review summarises some important new findings that implicate sphingosine-1-phosphate (SIP) as a potent tumorigenic and angiogenic agent released from cancerous tumours into the tumour microenvironment. Also explored is the novel concept that bioactive lipid signalling molecules, like SIP, can themselves be targets for rational drug design, thereby opening up an entire class of lipidomic-based therapeutics for oncology and other human diseases.

引用

收藏

页码：1131 / 1135

页数：5

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