Determination of the effectiveness of components of the herbal medicine Toki-Shakuyaku-San and fractions of Angelica acutiloba in improving the scopolamine-induced impairment of rat's spatial cognition in eight-armed radial maze test

被引:42
作者
Hatip-Al-Khatib, I
Egashira, N
Mishima, K
Iwasaki, K
Iwasaki, K
Kurauchi, K
Inui, K
Ikeda, T
Fujiwara, M
机构
[1] Fukuoka Univ, Adv Mat Inst, Jonan Ku, Fukuoka 8140180, Japan
[2] Paukkale Univ, Fac Med, Div Internal Med, Dept Pharmacol, TR-20070 Denizli, Turkey
[3] Fukuoka Univ, Fac Pharmaceut Sci, Dept Neuropharmacol, JOnan Ku, Fukuoka 8140180, Japan
[4] Miyazaki Univ, Miyazaki Med Coll, Dept Obstet & Gynecol, Miyazaki 8891692, Japan
关键词
Toki-Shakuyaku-San; Angelica acutiloba; N-methyl-beta-carboline-3-carboxamide; scopolamine; spatial memory;
D O I
10.1254/jphs.FPJ04015X
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The improving effects of various components of Toki-Shakuyaku-San (TSS) and fractions isolated from Angelica acutiloba Radix (Toki) on scopolamine-induced spatial memory impairment were investigated in eight-armed radial maze. The scopolamine-induced memory impairment was characterized by prominent increase of error choices in addition to decreased correct choices. Toki, Cnidium officinale Rhizoma (Senkyu), Poria cocos Hoelen (Bukuryo), Alisma orientale Rhizoma (Takusha), and Atractylodes lancea Rhizoma (Sojutsu) increased the correct choices, while only the Toki, Sojutsu, and Takusha decreased the error choices. No effect was produced by Paeonia lact flora Radix (Shakuyaku). Investigation of effects of fractions isolated from Toki revealed that its activity mainly resided in the butanol layer and its contents of N-methyl-beta-carboline-3-carboxamide and amines. Moreover, the alkaloid, internal and external solutions (containing poly-, di-, and monosaccharides) obtained by dialysis with Visking cellophane tubing also improved the memory. However, no improving properties were detected for methanol and hexanol layers, L-(-)-tryptophan, L-arginine, L-(-)-lysine, and choline chloride. The results showed that the TSS components could improve the reference and working memory impaired by scopolamine. The improving effect of TSS is produced greatly by the Toki component, the activity of which was greatly produced by the fraction extracted by butanol.
引用
收藏
页码:33 / 41
页数:9
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