Sequential Reassortments Underlie Diverse Influenza H7N9 Genotypes in China

被引：162

作者：

Wu, Aiping ^{[1
]}

Su, Chunhu ^{[3
]}

Wang, Dayan ^{[4
]}

Peng, Yousong ^{[5
]}

Liu, Mi ^{[1
,6
]}

Hua, Sha ^{[1
,6
]}

Li, Tianxian ^{[7
,8
]}

Gao, George F. ^{[9
]}

Tang, Hong ^{[2
,7
,8
]}

Chen, Jianzhu ^{[2
,10
,11
]}

Liu, Xiufan ^{[3
]}

Shu, Yuelong ^{[4
]}

Peng, Daxin ^{[3
]}

Jiang, Taijiao ^{[1
,5
]}

机构：

[1] Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Key Lab Prot & Peptide Pharmaceut, Beijing 100101, Peoples R China

[2] Chinese Acad Sci, Inst Biophys, CAS Key Lab Infect & Immun, Beijing 100101, Peoples R China

[3] Yangzhou Univ, Coll Vet Med, Yangzhou 225009, Jiangsu, Peoples R China

[4] China CDC, Natl Inst Viral Dis Control & Prevent, Beijing 100052, Peoples R China

[5] Hunan Univ, Coll Informat Sci & Engn, Changsha 410082, Hunan, Peoples R China

[6] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[7] Chinese Acad Sci, State Key Lab Virol, Wuhan 430071, Peoples R China

[8] Chinese Acad Sci, Wuhan Inst Virol, Wuhan 430071, Peoples R China

[9] Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China

[10] MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

[11] MIT, Dept Biol, Cambridge, MA 02139 USA

来源：

CELL HOST & MICROBE | 2013年 / 14卷 / 04期

基金：

中国国家自然科学基金;

关键词：

HUMAN INFECTION; VIRUS; ORIGIN; EMERGENCE;

D O I：

10.1016/j.chom.2013.09.001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Initial genetic characterizations have suggested that the influenza A (H7N9) viruses responsible for the current outbreak in China are novel reassortants. However, little is known about the pathways of their evolution and, in particular, the generation of diverse viral genotypes. Here we report an in-depth evolutionary analysis of whole-genome sequence data of 45 H7N9 and 42 H9N2 viruses isolated from humans, poultry, and wild birds during recent influenza surveillance efforts in China. Our analysis shows that the H7N9 viruses were generated by at least two steps of sequential reassortments involving distinct H9N2 donor viruses in different hosts. The first reassortment likely occurred in wild birds and the second in domestic birds in east China in early 2012. Our study identifies the pathways for the generation of diverse H7N9 genotypes in China and highlights the importance of monitoring multiple sources for effective surveillance of potential influenza outbreaks.

引用

页码：446 / 452

页数：7

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