The calf model of immunity for development of a vaccine against tuberculosis

被引:21
作者
Endsley, Janice J.
Waters, W. Ray [2 ]
Palmer, Mitchell V. [2 ]
Nonnecke, Brian J. [2 ]
Thacker, Tyler C. [2 ]
Jacobs, William R., Jr. [3 ]
Larsen, Michelle H. [3 ]
Hogg, Alison
Shell, Elisabeth
McAlauy, Martin [4 ]
Scherer, Charles F. Capinosh
Coffey, Tracey [4 ]
Howard, Chris J. [4 ]
Villareal-Ramos, Bernardo [4 ]
Estes, D. Mark [1 ]
机构
[1] Univ Texas Med Branch, Dept Pediat, Sealy Ctr Vaccine Dev, Galveston, TX 77555 USA
[2] Natl Anim Dis Ctr, Ames, IA 50010 USA
[3] Yeshiva Univ Albert Einstein Coll Med, Howard Hughes Med Inst, Bronx, NY 10461 USA
[4] Inst Anim Hlth, Compton RG20 7NN, England
基金
英国生物技术与生命科学研究理事会;
关键词
Tuberculosis; neonatal calf; prognostic; markers; MYCOBACTERIUM-BOVIS BCG; NATURAL-KILLER-CELLS; CYTOLYTIC T-CELLS; NEONATAL CALVES; ANTIMICROBIAL ACTIVITY; CATTLE; RESPONSES; PROTECTION; EXPRESSION; CHALLENGE;
D O I
10.1016/j.vetimm.2008.10.312
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Tuberculosis (TB) remains a major threat to public health. The identification of safe TB vaccine candidates beyond Mycobacterium bovis BCG, is an exciting prospect for control of human TB and necessary in the context of the human immunodeficiency virus (HIV) pandemic. Selection of vaccine candidates for human trials which are ultimately targeted for use in children less than 5 years of age or in newborns will require an animal model that closely approximates immune function and disease. We propose that the bovine neonate and adolescent is a robust animal model for preclinical safety and efficacy evaluation of TB candidate vaccines targeting this special human population. Parallel studies conducted in bovine neonates and non-human primates with a leading auxotrophic mutant with demonstrated efficacy/safety in a rodent TB model of TB demonstrated similar findings with respect to gross pathology scoring relative to BCG. The findings indicated more numerous and severe lesions in the lung in addition to higher levels of IFN-gamma producing cells. BCG vaccinates demonstrated higher levels of FoxP3 transcripts and lower levels of IL-4 mRNA. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码:199 / 204
页数:6
相关论文
共 46 条
[1]   Cattle as a model for development of vaccines against human tuberculosis [J].
Buddle, BM ;
Skinner, MA ;
Wedlock, DN ;
de Lisle, GW ;
Vordermeier, HM ;
Hewinson, RG .
TUBERCULOSIS, 2005, 85 (1-2) :19-24
[2]   Revaccination of neonatal calves with Mycobacterium bovis BCG reduces the level of protection against bovine tuberculosis induced by a single vaccination [J].
Buddle, BM ;
Wedlock, DN ;
Parlane, NA ;
Corner, LAL ;
de Lisle, GW ;
Skinner, MA .
INFECTION AND IMMUNITY, 2003, 71 (11) :6411-6419
[3]   Use of ESAT-6 in the interferon-γ test for diagnosis of bovine tuberculosis following skin testing [J].
Buddle, BM ;
Ryan, TJ ;
Pollock, JM ;
Andersen, P ;
de Lisle, GW .
VETERINARY MICROBIOLOGY, 2001, 80 (01) :37-46
[4]  
Calmette A, 1931, Proc R Soc Med, V24, P1481
[5]   Cellular responses and Mycobacterium bovis BCG growth inhibition by bovine lymphocytes [J].
Carpenter, E ;
Fray, L ;
Gormley, E .
IMMUNOLOGY AND CELL BIOLOGY, 1997, 75 (06) :554-560
[6]   Lymphocyte subtypes in experimentally induced early-stage bovine tuberculous lesions [J].
Cassidy, JP ;
Bryson, DG ;
Cancela, MMG ;
Forster, F ;
Pollock, JM ;
Neill, SD .
JOURNAL OF COMPARATIVE PATHOLOGY, 2001, 124 (01) :46-51
[7]   Antimicrobial activity of MHC class I-restricted CD8+T cells in human tuberculosis [J].
Cho, S ;
Mehra, V ;
Thoma-Uszynski, S ;
Stenger, S ;
Serbina, N ;
Mazzaccaro, RJ ;
Flynn, JL ;
Barnes, PF ;
Southwood, S ;
Celis, E ;
Bloom, BR ;
Modlin, RL ;
Sette, A .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (22) :12210-12215
[8]  
Cleaveland S, 2007, CURR TOP MICROBIOL, V315, P85
[9]   Granulysin-dependent killing of intracellular and extracellular Mycobacterium tuberculosis by Vγ9/Vδ2 T lymphocytes [J].
Dieli, F ;
Troye-Blomberg, M ;
Ivanyi, J ;
Fournié, JJ ;
Krensky, AM ;
Bonneville, M ;
Peyrat, MA ;
Caccamo, N ;
Sireci, G ;
Salerno, A .
JOURNAL OF INFECTIOUS DISEASES, 2001, 184 (08) :1082-1085
[10]   Mycobacterium bovis BCG vaccination induces memory CD4+ T cells characterized by effector biomarker expression and anti-mycobacterial activity [J].
Endsley, Janice J. ;
Hogg, Alison ;
Shell, Lis J. ;
McAulay, Martin ;
Coffey, Tracey ;
Howard, Chris ;
Scherer, Charles F. Capinos ;
Waters, W. Ray ;
Nonnecke, Brian ;
Estes, D. Mark ;
Villarreal-Ramos, Bernardo .
VACCINE, 2007, 25 (50) :8384-8394