Role of protein tyrosine phosphatase-1B in diabetes and obesity

被引：40

作者：

Kennedy, BP ^{[1
]}

机构：

[1] Merck Frosst Ctr Therapeut Res, Dept Biochem & Mol Biol, Pointe Claire, PQ H9R 4P8, Canada

来源：

BIOMEDICINE & PHARMACOTHERAPY | 1999年 / 53卷 / 10期

关键词：

obesity; PTP-1B; type; 2; diabetes;

D O I：

10.1016/S0753-3322(00)88105-6

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Type 2 or non-insulin-dependent diabetes mellitus (NIDDM) is reaching epidemic proportions in industrialized countries. Obesity is a major factor in this disease, since about 75% of obese individuals will develop type 2 diabetes. There is an urgent need to develop new therapies for these diseases. Recently, the protein tyrosine phosphatase PTP-1B has been shown to he a negative regulator of the insulin signaling pathway, suggesting that inhibitors of this enzyme may be beneficial in the treatment of type 2 diabetes. Mice lacking PTP-1B are resistant to both diabetes and obesity. (C) 1999 Editions scientifques et medicales Elsevier SAS.

引用

页码：466 / 470

页数：5

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