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Platelet prostanoid receptors

被引：73
作者：
Armstrong, RA
机构：
[1] Dept. of Dietetics and Nutrition, Queen Margaret College, Edinburgh, EH12 8TS, Clerwood Terrace
来源：
PHARMACOLOGY & THERAPEUTICS | 1996年 / 72卷 / 03期
关键词：
human platelets; thromboxane (TP) receptors; prostacyclin (IF) receptors; PGD(2) (DP) receptors; PGE(2) (EP(3)) receptors; isoprostanes;
D O I：
10.1016/S0163-7258(96)00103-9
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Prostaglandins (PGs) and thromboxanes are important modulators of platelet activation, and there is strong evidence to support the existence of distinct thromboxane, prostacyclin, PGD(2) and PGE(2) receptors on the platelet plasma membrane. In this review, each of these platelet prostanoid receptors is discussed in detail, with respect to their receptor pharmacology, molecular biology and signal transduction, and as to any therapeutic implications of the development of specific agonists and/or antagonists. In addition, it considers the possibility that there are separate vascular receptors for 8-epi PGF(2 alpha), which are not present on the platelet. Copyright (C) 1996 Elsevier Science Inc.
引用
收藏
页码：171 / 191
页数：21
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