Intestinal epithelial cell apoptosis following Cryptosporidium parvum infection

被引：113

作者：

McCole, DF

Eckmann, L

Laurent, F

Kagnoff, MF

机构：

[1] Univ Calif San Diego, Dept Med 0623D, Lab Mucosal Immunol, La Jolla, CA 92093 USA

[2] INRA, Ctr Tours, Lab Protozool, F-37380 Nouzilly, France

来源：

INFECTION AND IMMUNITY | 2000年 / 68卷 / 03期

关键词：

D O I：

10.1128/IAI.68.3.1710-1713.2000

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cryptosporidium parvum induces moderate levels of apoptosis of cultured human intestinal epithelial cells which are maximal at 24 h after infection. Apoptosis is further increased in C. parvum-infected cell by inhibition of NF-KB. C. parvum infection also attenuates epithelial apoptosis induced by strongly proapoptotic agents. The data suggest C. parvum has developed strategies to limit apoptosis in order to facilitate its growth and maturation in the early period after epithelial cell infection.

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页码：1710 / 1713

页数：4

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