New Therapeutic Concepts in Bile Acid Transport and Signaling for Management of Cholestasis

被引：218

作者：

Trauner, Michael ^{[1
]}

Fuchs, Claudia Daniela ^{[1
]}

Halilbasic, Emina ^{[1
]}

Paumgartner, Gustav ^{[1
]}

机构：

[1] Med Univ Vienna, Dept Internal Med 3, Div Gastroenterol & Hepatol, Waehringer Guertel 18-20, A-1090 Vienna, Austria

来源：

HEPATOLOGY | 2017年 / 65卷 / 04期

关键词：

FARNESOID-X-RECEPTOR; PRIMARY BILIARY-CIRRHOSIS; PLACEBO-CONTROLLED TRIAL; HEPATITIS-B-VIRUS; FAMILIAL INTRAHEPATIC CHOLESTASIS; GLUCAGON-LIKE PEPTIDE-1; GROWTH-FACTOR; 19; SCLEROSING CHOLANGITIS; URSODEOXYCHOLIC ACID; NUCLEAR RECEPTOR;

D O I：

10.1002/hep.28991

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

The identification of the key regulators of bile acid ( BA) synthesis and transport within the enterohepatic circulation has revealed potential targets for pharmacological therapies of cholestatic liver diseases. Novel drug targets include the bile BA receptors, farnesoid X receptor and TGR5, the BA-induced gut hormones, fibroblast growth factor 19 and glucagon-like peptide 1, and the BA transport systems, apical sodium-dependent bile acid transporter and Na+-taurocholate cotransporting polypeptide, within the enterohepatic circulation. Moreover, BA derivatives undergoing cholehepatic shunting may allow improved targeting to the bile ducts. This review focuses on the pathophysiological basis, mechanisms of action, and clinical development of novel pharmacological strategies targeting BA transport and signaling in cholestatic liver diseases.

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收藏

页码：1393 / 1404

页数：12

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