Behaviors and neurodegeneration induced by two blockers of K+ channels, the mast cell degranulating peptide and Dendrotoxin I

被引：12

作者：

Mourre, C

Lazdunski, M

Jarrard, LE

机构：

[1] INST PHARMACOL MOL & CELLULAIRE,CNRS,UPR 411,VALBONNE,FRANCE

[2] WASHINGTON & LEE UNIV,DEPT PSYCHOL,LEXINGTON,VA 24450

来源：

BRAIN RESEARCH | 1997年 / 762卷 / 1-2期

关键词：

toxicity; voltage-dependent K+ channel; brain damage; seizure; hippocampus; cerebellum;

D O I：

10.1016/S0006-8993(97)00481-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Both the Mast Cell Degranulating (MCD) peptide and Dendrotoxin I (DTXI), two blockers of fast activation and slowly inactivating K+ channels, induced epileptiform seizures and brain damage after intracerebroventricular injection (200 pmol) in Sprague-Dawley rats. A considerable variation in the response of the rats was observed for each toxin. The neurodegeneration included the hippocampal formation, subiculum, septum, amygdala, and the cerebellum for both toxins, and the neocortex and anterior thalamic nuclei exclusively for DTXI treatment. (C) 1997 Elsevier Science B.V.

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收藏

页码：223 / 227

页数：5

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