Anti-human immunodeficiency virus-type 1 activity of constituents from Juglans mandshurica

被引：106

作者：

Min, BS ^{[1
]}

Lee, HK

Lee, SM

Kim, YH

Bae, KH

Otake, T

Nakamura, N

Haftori, M

机构：

[1] KRIBB, Immunomodulator Res Lab, Taejon 305600, South Korea

[2] Osaka Prefectural Inst Publ Hlth, Osaka 537, Japan

[3] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

[4] Toyama Med & Pharmaceut Univ, Inst Nat Med, Toyama 9300194, Japan

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2002年 / 25卷 / 04期

关键词：

Juglans mandshurica; taxifolin; anti-HIV activity; MT-4; cells;

D O I：

10.1007/BF02976598

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Three naphthalene glycosides (1-3), four flavonoids (4-7), and two galloyl glycosides (8-9) were isolated from the stem-bark of Juglans mandshurica (Juglandaceae). Their structures were determined by chemical and spectral means, including to 2D-NMR (COSY, HMQC, and HMBC) experiments. Amongst the isolated compounds, taxifolin (4) showed the most potent HIV-induced cytopethic activity against MT-4 cells with complete inhibitory concentration (IC100) value of 25 mug/ml and maximum cytotoxic concentration (CC100) value of above 100 mug/ml. However, naphthalene glycosides (1-3), flavonoids (5-7)), and galloyl tannins (8-9) were inactive against anti-HIV-1 activity.

引用

页码：441 / 445

页数：5

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