Molecular biology - Introns gain ground

被引：12

作者：

Eickbush, TH ^{[1
]}

机构：

[1] Univ Rochester, Dept Biol, Rochester, NY 14627 USA

来源：

NATURE | 2000年 / 404卷 / 6781期

关键词：

D O I：

10.1038/35010246

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Introns are seemingly useless gene segments in eukaryotes. One view is that they originated from mobile elements called type II introns that occur, for instance, in bacteria. That possibility finds support in work revealing a way in which type II introns can spread throughout a genome.

引用

收藏

页码：940 / 943

页数：4

相关论文

共 10 条

[1] SELF-SPLICING RNA - IMPLICATIONS FOR EVOLUTION [J].

CECH, TR .

INTERNATIONAL REVIEW OF CYTOLOGY-A SURVEY OF CELL BIOLOGY, 1985, 93 :3-22

[2] Retrohoming of a bacterial group II intron: Mobility via complete reverse splicing, independent of homologous DNA recombination [J].

Cousineau, B ;

Smith, D ;

Lawrence-Cavanagh, S ;

Mueller, JE ;

Yang, J ;

Mills, D ;

Manias, D ;

Dunny, G ;

Lambowitz, AM ;

Belfort, M .

CELL, 1998, 94 (04) :451-462

[3] Retrotransposition of a bacterial group II intron [J].

Cousineau, B ;

Lawrence, S ;

Smith, D ;

Belfort, M .

NATURE, 2000, 404 (6781) :1018-1021

[4] Mobility of yeast mitochondrial group II introns: Engineering a new site specificity and retrohoming via full reverse splicing [J].

Eskes, R ;

Yang, JA ;

Lambowitz, AM ;

Perlman, PS .

CELL, 1997, 88 (06) :865-874

[5] SELF-SPLICING GROUP-II AND NUCLEAR PRE-MESSENGER-RNA INTRONS - HOW SIMILAR ARE THEY [J].

JACQUIER, A .

TRENDS IN BIOCHEMICAL SCIENCES, 1990, 15 (09) :351-354

[6] A bacterial group II intron encoding reverse transcriptase, maturase, DNA endonuclease activities: biochemical demonstration of maturase activity and insertion of new genetic information within the intron [J].

Matsuura, M ;

Saldanha, R ;

Ma, HW ;

Wank, H ;

Yang, J ;

Mohr, G ;

Cavanagh, S ;

Dunny, GM ;

Belfort, M ;

Lambowitz, AM .

GENES & DEVELOPMENT, 1997, 11 (21) :2910-2924

[7] STRUCTURE AND ACTIVITIES OF GROUP-II INTRONS [J].

MICHEL, F ;

FERAT, JL .

ANNUAL REVIEW OF BIOCHEMISTRY, 1995, 64 :435-461

[8]

Mohr G, 2000, GENE DEV, V14, P559

[9] ON THE ORIGIN OF RNA SPLICING AND INTRONS [J].

SHARP, PA .

CELL, 1985, 42 (02) :397-400

[10] Identification of the endonuclease domain encoded by R2 and other site-specific, non-long terminal repeat retrotransposable elements [J].

Yang, J ;

Malik, HS ;

Eickbush, TH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (14) :7847-7852