Bisphosphonates in the adjuvant treatment of cancer: experimental evidence and first clinical results

被引:19
作者
Diel, IJ
Mundy, GR
机构
[1] Univ Heidelberg, Dept Ob Gyn, D-69115 Heidelberg, Germany
[2] Univ Texas, Hlth Sci Ctr, San Antonio, TX USA
关键词
bone metastases; bisphosphonates; prevention; prophylaxis;
D O I
10.1054/bjoc.1999.1077
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Several animal models, as well as a number of cell culture experiments, indicate a prophylactic effect of bisphosphonates in respect of subsequent bone metastasis. Moreover, in preliminary clinical trials involving patients with advanced breast cancer and local or remote metastases, biophosphonates produced a reduction in new skeletal metastases. This overview summarizes and discusses the results of the latest investigations. It opens with a section on the pathophysiology of bone metastasis, which is followed by a report on animal models and first studies of bisphosphonate treatment as a new approach in systemic adjuvant therapy. (C) 2000 Cancer Research Campaign.
引用
收藏
页码:1381 / 1386
页数:6
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