Emerging therapies for the treatment of hepatitis C

被引：86

作者：

Lange, Christian M. ^{[1
]}

Jacobson, Ira M. ^{[2
]}

Rice, Charles M. ^{[3
]}

Zeuzem, Stefan ^{[1
]}

机构：

[1] Klinikum JW Goethe Univ Frankfurt, Med Klin 1, Frankfurt, Germany

[2] Weill Cornell Med Coll, New York, NY USA

[3] Rockefeller Univ, Ctr Study Hepatitis C, Lab Virol & Infect Dis, New York, NY 10021 USA

来源：

EMBO MOLECULAR MEDICINE | 2014年 / 6卷 / 01期

关键词：

directly acting antiviral agents; NS5B polymerase inhibitor; NS3-4A protease inhibitor; interferon-free; hepatitis C virus; INTERFERON-ALPHA-2B PLUS RIBAVIRIN; TREATMENT-NAIVE PATIENTS; PEGINTERFERON ALPHA-2A; DOUBLE-BLIND; NON-A; GENOTYPE-1; INFECTION; COMBINATION THERAPY; PROTEASE INHIBITOR; ANTIVIRAL THERAPY; INITIAL TREATMENT;

D O I：

10.1002/emmm.201303131

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Opportunities to treat infection with hepatitis C virus (HCV) are evolving rapidly. From the introduction of interferon-alpha monotherapy in 1992 to the approval of telaprevir- and boceprevir-based triple therapies with pegylated interferon-alpha and ribavirin in 2011, the chances of curing patients infected with HCV genotype 1 have improved from <10% to approximately 70%. Significant further improvements are on the horizon, which may well cure virtually all hepatitis C patients with an all-oral, interferon-free regimen in the very near future. These exciting developments are reviewed in the present article.

引用

页码：4 / 15

页数：12

共 81 条

[1] Valopicitabine (NM283), alone or with peginterferon, compared to peg interferon/ribavirin (pegIFN/RBV) retreatment in patients with HCV-1 infection and prior non-response to pegIFN/RBV: One-year results [J].

Afdhal, N. ;

O'Brien, C. ;

Godofsky, E. ;

Rodriguez-Torres, M. ;

Pappas, S. C. ;

Lawitz, E. ;

Pockros, P. ;

Sulkowski, M. ;

Jacobson, I. ;

Chao, G. ;

Knox, S. ;

Pietropaolo, K. ;

Brown, N. A. .

JOURNAL OF HEPATOLOGY, 2007, 46 :S5-S5

[2]

ALTER HJ, 1978, LANCET, V1, P459

[3] Boceprevir for Previously Treated Chronic HCV Genotype 1 Infection [J].

Bacon, Bruce R. ;

Gordon, Stuart C. ;

Lawitz, Eric ;

Marcellin, Patrick ;

Vierling, John M. ;

Zeuzem, Stefan ;

Poordad, Fred ;

Goodman, Zachary D. ;

Sings, Heather L. ;

Poordad, Fred ;

Goodman, Zachary D. ;

Sings, Heather L. ;

Boparai, Navdeep ;

Burroughs, Margaret ;

Brass, Clifford A. ;

Albrecht, Janice K. ;

Esteban, Rafael .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (13) :1207-1217

[4] Novel insights into hepatitis C virus replication and persistence [J].

Bartenschlager, R ;

Frese, M ;

Pietschmann, T .

ADVANCES IN VIRUS RESEARCH, VOL. 63, 2004, 63 :71-+

[5] The molecular and structural basis of advanced antiviral therapy for hepatitis C virus infection [J].

Bartenschlager, Ralf ;

Lohmann, Volker ;

Penin, Francois .

NATURE REVIEWS MICROBIOLOGY, 2013, 11 (07) :482-496

[6] Prediction of treatment outcome in patients with chronic hepatitis C: Significance of baseline parameters and viral dynamics during therapy [J].

Berg, T ;

Sarrazin, C ;

Herrmann, E ;

Hinrichsen, H ;

Gerlach, T ;

Zachoval, R ;

Wiedenmann, B ;

Hopf, U ;

Zeuzem, S .

HEPATOLOGY, 2003, 37 (03) :600-609

[7] HEPATITIS C [J].

Brody, Herb .

NATURE, 2011, 474 (7350) :CP17-CP17

[8] ISOLATION OF A CDNA CLONE DERIVED FROM A BLOOD-BORNE NON-A, NON-B VIRAL-HEPATITIS GENOME [J].

CHOO, QL ;

KUO, G ;

WEINER, AJ ;

OVERBY, LR ;

BRADLEY, DW ;

HOUGHTON, M .

SCIENCE, 1989, 244 (4902) :359-362

[9] Effect of IL28B Genotype on Early Viral Kinetics During Interferon-Free Treatment of Patients With Chronic Hepatitis C [J].

Chu, Tom W. ;

Kulkarni, Rohit ;

Gane, Edward J. ;

Roberts, Stuart K. ;

Stedman, Catherine ;

Angus, Peter W. ;

Ritchie, Brett ;

Lu, Xiao-Yu ;

Ipe, David ;

Lopatin, Uri ;

Germer, Soren ;

Iglesias, Victor A. ;

Elston, Robert ;

Smith, Patrick F. ;

Shulman, Nancy S. .

GASTROENTEROLOGY, 2012, 142 (04) :790-795

[10] Aging of Hepatitis C Virus (HCV)-Infected Persons in the United States: A Multiple Cohort Model of HCV Prevalence and Disease Progression [J].

Davis, Gary L. ;

Alter, Miriam J. ;

El-Serag, Hashem ;

Poynard, Thierry ;

Jennings, Linda W. .

GASTROENTEROLOGY, 2010, 138 (02) :513-U141

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