Osteocytes use estrogen receptor α to respond to strain but their ERα content is regulated by estrogen

被引：101

作者：

Zaman, Gul ^{[1
]}

Jessop, Helen L. ^{[1
]}

Muzylak, Mariusz ^{[1
]}

De Souza, Roberto L. ^{[1
]}

Pitsillides, Andrew A. ^{[1
]}

Price, Joanna S. ^{[1
]}

Lanyon, Lance L. ^{[1
]}

机构：

[1] Univ London Royal Vet Coll, Dept Basic Sci, London NW1 0TU, England

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2006年 / 21卷 / 08期

关键词：

osteocytes; mechanical loading; estrogen; bone; osteoporosis;

D O I：

10.1359/JBMR.060504

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The role of mechanical strain and estrogen status in regulating ER alpha levels in bone cells was studied in female rats. OVX is associated with decreased ER alpha protein expression/osteocyte, whereas habitual strain and artificial loading has only a small but positive effect, except on the ulna's medial surface, where artificial loading stimulates reversal of resorption to formation.

引用

页码：1297 / 1306

页数：10

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