Intravenous transplantation of bone marrow mesenchymal stem cells promotes neural regeneration after traumatic brain injury

被引：53

作者：

Anbari, Fatemeh ^{[1
]}

Khalili, Mohammad Ali ^{[1
]}

Bahrami, Ahmad Reza ^{[2
]}

Khoradmehr, Arezoo ^{[1
]}

Sadeghian, Fatemeh ^{[1
]}

Fesahat, Farzaneh ^{[1
]}

Nabi, Ali ^{[1
]}

机构：

[1] Shahid Sadoughi Univ Med Sci, Res & Clin Ctr Infertil, Yazd, Iran

[2] Ferdowsi Univ Mashhad, Inst Biotechnol, Mashhad, Iran

来源：

NEURAL REGENERATION RESEARCH | 2014年 / 9卷 / 09期

关键词：

nerve regeneration; bone marrow mesenchymal stem cells; traumatic brain injury; intravenous administration; cell differentiation; neurologic function; cerebral cortex; rats; neural regeneration; STROMAL CELLS; THERAPEUTIC BENEFIT; FUNCTIONAL RECOVERY; RATS; NEUROGENESIS; TRANSMIGRATE; STROKE; MODEL;

D O I：

10.4103/1673-5374.133133

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

To investigate the supplement of lost nerve cells in rats with traumatic brain injury by intravenous administration of allogenic bone marrow mesenchymal stem cells, this study established a Wistar rat model of traumatic brain injury by weight drop impact acceleration method and administered 3 x 106 rat bone marrow mesenchymal stem cells via the lateral tail vein. At 14 days after cell transplantation, bone marrow mesenchymal stem cells differentiated into neurons and astrocytes in injured rat cerebral cortex and rat neurological function was improved significantly. These findings suggest that intravenously administered bone marrow mesenchymal stem cells can promote nerve cell regeneration in injured cerebral cortex, which supplement the lost nerve cells.

引用

页码：919 / 923

页数：5

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