A genetic map and recombination parameters of the human malaria parasite Plasmodium falciparum

被引:278
作者
Su, XZ
Ferdig, MT
Huang, YM
Huynh, CQ
Liu, A
You, JT
Wootton, JC
Wellems, TE [1 ]
机构
[1] NIAID, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA
[2] Guangxi Inst Parasit Dis Control, Nanning, Guangxi, Peoples R China
[3] Natl Lib Med, Computat Biol Branch, Natl Ctr Biotechnol Informat, NIH, Bethesda, MD 20894 USA
关键词
D O I
10.1126/science.286.5443.1351
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Genetic investigations of malaria require a genome-wide, high-resolution Linkage map of Plasmodium falciparum. A genetic cross was used to construct such a map from 901 markers that fall into 14 inferred Linkage groups corresponding to the 14 nuclear chromosomes. Meiotic crossover activity in the genome proved high (17 kilobases per centimorgan) and notably uniform over chromosome length. Gene conversion events and spontaneous microsatellite length changes were evident in the inheritance data. The markers, map, and recombination parameters are facilitating genome sequence assembly, Localization of determinants for such traits as virulence and drug resistance, and genetic studies of parasite field populations.
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页码:1351 / 1353
页数:3
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