G-quartet formation from an N2-modified guanosine derivative

被引：34

作者：

Liu, Xiangyang ^{[1
]}

Kwan, Irene C. M. ^{[1
]}

Wang, Suning ^{[1
]}

Wu, Gang ^{[1
]}

机构：

[1] Queens Univ, Dept Chem, Kingston, ON K7L 3N6, Canada

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 17期

关键词：

D O I：

10.1021/ol061236w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report G-quartet formation from an N-2-modified lipophilic guanosine nucleoside, N-2-(4-n-butylphenyl)-2', 3', 5'-O-triacetylguanosine. We show that, in the presence of either K+ or Na+, this guanosine derivative self-assembles into a D-4-symmetric octamer consisting of two stacking all-syn G-quartets in a tail-to-tail (or head-to-head) fashion and a central ion.

引用

页码：3685 / 3688

页数：4

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