Delta opioid binding selectivity of 3-ether analogs of naltrindole

被引：9

作者：

Coop, A

Pinto, J

Wang, LJ

McCullough, K

Rothman, RB

Dersch, C

Jacobson, AE

Rice, KC

机构：

[1] NIDDKD, Med Chem Lab, Bethesda, MD 20892 USA

[2] Natl Inst Drug Abuse, Addict Res Ctr, Clin Psychopharmacol Sect, Baltimore, MD 21224 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 24期

关键词：

D O I：

10.1016/S0960-894X(99)00622-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Masking of the 3-phenol of naltrindole as a range of ethers caused a decrease in binding affinity at all three opiate receptors (mu, kappa, delta), however for the methyl ether, the reduction in affinity at both mu and kappa was greater than at delta, thereby increasing delta binding selectivity. (C) 1999 Published by Elsevier Science Ltd.

引用

收藏

页码：3435 / 3438

页数：4

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